Friday July 20, 2007
Efren and I arrived at Conte by 7:30. He set up the X-Ray Reflectometer while I spin coated some films.
These structures are used in Boron Neutron Capture Therapy; the structures are incorporated into tumor tissues then bombarded with neutrons. The result is site specific, isolated radiation therapy. The
carboranes accumulate in the tumors because of the high
vascularity of tumors and the increased "leakiness" of the tumor capillaries because of decreased cell to cell junctions (a function of rapid
angiogenesis). While tumors display a high rate of
angiogenesis, they do not show an increase in lymph vessel proliferation. As a result the
carboranes enter the tumor but are not drained out, therefore they accumulate there.
Carboranes that do not accumulate in the tumor are cleared from the blood by the kidneys and excreted. The accumulated
carboranes are then excited by a neutron beam aimed just at the tumor. More on
carborane structure can be found
here.The remainder of the day was spent measuring thicknesses of films and measuring wrinkle patterns obtained on Thursday.
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